Our dog Tank would get sprayed once or twice every year. Best de-skunk solution I have found is- 1 qt. 3% (fresh, unopened) hydrogen peroxide. 1/4 cup baking soda 1-2 tsp dish soap Mix ingredients in a bowl right before you apply it. Application methods vary but I have found that pouring the mixture into an old squeezable water bottle works best or one of those plastic picnic catchup/mustard bottles. Leave the top open, the reaction between the peroxide and baking soda will cause pressure build up in a closed container and may burst. Use a washrag to apply around muzzle and face, taking caution to avoid eyes. Wear latex gloves if you have them and work the solution into the affected areas. Let set 5-7 minutes. Do not wet your dog with water until after the solution has set for the 5-7 minutes. Rinse and repeat if necessary.